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Related Concept Videos

Endocrine Signaling01:45

Endocrine Signaling

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Endocrine cells produce hormones to communicate with remote target cells found in other organs. The hormone reaches these distant areas using the circulatory system. This exposes the whole organism to the hormone but only those cells expressing hormone receptors or target cells are affected. Thus, endocrine signaling induces slow responses from its target cells but these effects also last longer.
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What is the Endocrine System?00:46

What is the Endocrine System?

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The endocrine system sends hormones—chemical signals—through the bloodstream to target cells—the cells the hormones selectively affect. These signals are produced in endocrine cells, secreted into the extracellular fluid, and then diffuse into the blood. Eventually, they diffuse out of the blood and bind to target cells which have specialized receptors to recognize the hormones.
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The Endocrine System01:29

The Endocrine System

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The endocrine system is an extensive network of glands – organs or tissues in the body that create chemicals that control many bodily functions, that secrete hormones, which are chemical messengers that play essential roles in regulating various bodily functions. These hormones are secreted into the bloodstream and travel throughout the body. They require specific receptors to convey signals to cells possessing these corresponding receptors. This complex signaling mechanism ensures that...
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An Overview of the Endocrine System01:10

An Overview of the Endocrine System

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The endocrine system, a complex network of glands, orchestrates physiological balance within the body through the production and secretion of hormones. These hormones are chemical messengers in intercellular communication, acting as conduits between the secretory cells and distant target sites. They traverse the circulatory system by being released into the extracellular fluid, and their impact is specific to cells possessing receptors for a particular hormone.
The endocrine system collaborates...
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Structures of the Endocrine System00:59

Structures of the Endocrine System

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The intricate framework of the endocrine system encompasses a diverse array of glands, with their target tissues and organs strategically distributed throughout the body. Central to this network are the endocrine glands, specialized structures that lack ducts and release hormones directly into the interstitial fluid. Notably, the hypothalamus, a vital neuroendocrine organ situated in the brain, governs neural functions and serves as a potent source of hormonal regulation. Near the hypothalamus...
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Chemical Signaling in the Endocrine System01:08

Chemical Signaling in the Endocrine System

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A signaling cascade is a series of events that facilitates the transmission of information within or between cells, culminating in a targeted response in the recipient cell. As chemical messengers, hormones are pivotal in initiating and modulating these intricate signaling cascades based on their solubility.
Lipid-soluble hormones, such as steroid hormones, demonstrate an intracellular action. These hormones traverse cell membranes due to their lipid nature. Once inside the target cell, they...
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A High-Throughput Electrochemiluminescence 7-Plex Assay Simultaneously Screening for Type 1 Diabetes and Multiple Autoimmune Diseases
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Multiple endocrine neoplasia type 1.

Cornelis Jm Lips1, Koen Dreijerink2, Thera P Links3

  • 1a University Medical Center Utrecht, Department of Internal Medicine, Wassenaarseweg 109, 2596 CN The Hague, The Netherlands. lips05@zonnet.nl.

Expert Review of Endocrinology & Metabolism
|February 21, 2019
PubMed
Summary
This summary is machine-generated.

Multiple endocrine neoplasia type 1 (MEN1) is an inherited tumor syndrome. Early diagnosis and treatment improve life expectancy and quality of life for MEN1 patients.

Keywords:
DNA diagnosisMEN 1genetic testingmeninmultiple endocrine neoplasia type 1mutation analysisperiodic clinical monitoringpresymptomatic treatment

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Area of Science:

  • Endocrinology
  • Genetics
  • Oncology

Background:

  • Multiple endocrine neoplasia type 1 (MEN1) is an autosomal-dominant inherited tumor syndrome.
  • MEN1 is characterized by tumors in endocrine glands like parathyroid, pituitary, and pancreas, as well as nonendocrine tissues.
  • The MEN1 gene, identified in 1997, encodes the tumor suppressor protein menin.

Purpose of the Study:

  • To review current guidelines for early diagnosis and treatment of MEN1.
  • To explore the function of menin and its interactions.
  • To discuss future therapeutic strategies for MEN1.

Main Methods:

  • Review of existing literature and clinical guidelines for MEN1.
  • Analysis of MEN1 gene mutations for diagnosis.
  • Identification and study of menin-interacting proteins.

Main Results:

  • Established guidelines for early diagnosis (including genetic testing) and treatment (including clinical monitoring) improve patient outcomes.
  • Menin's function involves regulating gene transcription, proliferation, apoptosis, genome stability, DNA repair, and metabolic homeostasis.
  • Understanding menin's interactions provides insights into MEN1 pathogenesis.

Conclusions:

  • Early diagnosis and proactive management significantly enhance life expectancy and quality of life for individuals with MEN1.
  • Further research into menin's molecular functions may lead to targeted therapies.
  • Future interventions aim to prevent or delay the onset of MEN1-related tumors.