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Coenzyme Q10 and Degenerative Disorders Affecting Longevity: An Overview
David Mantle1, Iain Hargreaves2
1Pharma Nord (UK) Ltd., Telford Court, Morpeth, NE61 2DB Northumberland, UK. dmantle@pharmanord.co.uk.
Antioxidants (Basel, Switzerland)
|February 21, 2019
Summary
Coenzyme Q10 (CoQ10) supplementation shows significant potential in promoting longevity by reducing mortality and managing degenerative diseases like cardiovascular, diabetes, kidney, and liver conditions.
Area of Science:
- Biochemistry
- Gerontology
- Nutritional Science
Background:
- Longevity is influenced by genetic, environmental, and lifestyle factors.
- Degenerative disorders (cardiovascular, diabetes, kidney, liver disease) significantly impact lifespan, especially when co-morbid.
- Coenzyme Q10 (CoQ10) is a vital compound in cellular energy production and possesses antioxidant properties.
Purpose of the Study:
- To review the potential role of Coenzyme Q10 (CoQ10) supplementation in preventing or managing major degenerative disorders.
- To explore CoQ10's impact on longevity and age-related diseases.
Main Methods:
- Review of randomized controlled clinical trials.
- Analysis of studies investigating CoQ10 supplementation in cardiovascular disease, type II diabetes, chronic kidney disease, and non-alcoholic fatty liver disease.
Main Results:
- CoQ10 supplementation reduced mortality by approximately 50% in cardiovascular disease patients and the elderly population.
- CoQ10 improved glycemic control and vascular function in type II diabetes.
- CoQ10 enhanced renal function in chronic kidney disease and reduced liver inflammation in non-alcoholic fatty liver disease.
Conclusions:
- Coenzyme Q10 (CoQ10) supplementation demonstrates a significant beneficial role in managing major degenerative disorders.
- CoQ10's positive effects are attributed to its functions in cellular energy generation, antioxidant activity, and anti-inflammatory properties.
- CoQ10 supplementation may be a valuable strategy for promoting longevity and improving health outcomes in aging populations.
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