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Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs
Published on: January 17, 2020
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Paper-based microfluidic devices for glucose assays employing a metal-organic framework (MOF)
Grenalynn C Ilacas1, Alexis Basa1, Katherine J Nelms1
1Department of Chemistry and Biochemistry, California State University, Los Angeles, 5151 State University Drive, Los Angeles, CA 90032-8202, USA.
Analytica Chimica Acta
|February 21, 2019
Summary
Researchers developed two microfluidic paper-based analytical devices (μPADs) using a metal-organic framework (MOF) to detect glucose. These novel sensors offer a promising approach for accessible glucose monitoring.
Area of Science:
- Analytical Chemistry
- Materials Science
- Biomedical Engineering
Background:
- Microfluidic paper-based analytical devices (μPADs) offer low-cost, portable sensing platforms.
- Metal-organic frameworks (MOFs) show potential as stable and efficient enzyme immobilization matrices.
- Accurate glucose detection is crucial for diabetes management and biochemical analysis.
Purpose of the Study:
- To develop and characterize two distinct μPAD configurations for glucose detection.
- To utilize a novel MOF, Zr-PCN-222(Fe), for encapsulating glucose oxidase (GOx).
- To establish a colorimetric assay for quantifying glucose concentrations using the developed μPADs.
Main Methods:
- Fabrication of a well-based μPAD and a lateral flow assay (LFA) μPAD.
- Immobilization of glucose oxidase (GOx) within the Zr-PCN-222(Fe) MOF.
- Colorimetric detection of glucose via reaction with KI and GOx@MOF, followed by image analysis.
Main Results:
- Both μPAD designs successfully detected glucose through a colorimetric reaction, producing a yellow-brown to brown color.
- A quantifiable correlation was established between the inverse yellow intensity and glucose concentration.
- The MOF-based encapsulation provided a stable platform for the enzyme within the μPADs.
Conclusions:
- The developed μPADs, utilizing MOFs as biomimetic catalysts, demonstrate effective glucose sensing capabilities.
- These devices present a viable, low-cost alternative for glucose monitoring.
- The integration of MOFs in microfluidic devices broadens their application in sensing various analytes.
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