Kimura's disease associated with IgA nephropathy: A case report

Area of Science:

• Nephrology
• Immunology
• Dermatology

Background:

• Kimura's disease (KD) is a rare chronic inflammatory condition typically presenting with subcutaneous lesions in the head and neck.
• It is characterized by peripheral eosinophilia and elevated serum Immunoglobulin E (IgE) levels, predominantly affecting young Asian males.
• Renal involvement in KD is documented, but IgA nephropathy is an uncommon finding.

Purpose of the Study:

• To report a rare case of Kimura's disease presenting with IgA nephropathy in an atypical location (elbow).
• To evaluate the efficacy of methylprednisone and cyclophosphamide in treating this rare presentation of KD-associated IgA nephropathy.

Main Methods:

• A case study of a middle-aged Chinese man with Kimura's disease and IgA nephropathy.
• Treatment involved 6 months of pulse therapy with methylprednisone and cyclophosphamide.

Main Results:

• The patient presented with an atypical subcutaneous lesion on the elbow and concurrent IgA nephropathy.
• The combined treatment regimen of methylprednisone and cyclophosphamide was effective in managing the condition.
• No relapse of nephrotic syndrome was observed during the 6-month follow-up period.

Conclusions:

• Methylprednisone combined with cyclophosphamide is an effective treatment for Kimura's disease-associated IgA nephropathy.
• Long-term methylprednisone administration may play a role in preventing the recurrence of Kimura's disease.