Related Experiment Video
Updated: Jan 28, 2026

Cell Death Associated with Abnormal Mitosis Observed by Confocal Imaging in Live Cancer Cells
Published on: August 21, 2013
Live or Let Die: T Cell Survival in Cancer Immunotherapy
Janne Ruotsalainen1, Thomas Tüting1
1Laboratory of Experimental Dermatology, Department of Dermatology, Otto-von-Guericke University, Magdeburg, Germany.
Abstract:
Combination immune checkpoint blockade targeting CTLA-4 and PD-1 is thought to reinvigorate exhausted T cells better than monotherapies. In this issue of Immunity, Pai et al. (2019) show that, in the setting of low tumor burden, this combination regimen promotes interferon-γ-dependent T cell hyperactivation and death and thus favors tumor progression.
Related Concept Videos
Cancer Survival Analysis
Kubler Ross's Stages of Dying
In denial, individuals reject the reality of their condition, often thinking, "This isn't true; I feel fine," as a way to protect themselves from...
Tumor Immunotherapy
Survival Curves
The Kaplan-Meier estimator is the most common method for constructing survival curves. This...
Survival Tree
Building a Survival Tree
Constructing a...
Introduction To Survival Analysis
The primary goal of survival analysis is to estimate survival time—the time...

