Related Experiment Video
Updated: Jan 28, 2026

Accessing the Cytotoxicity and Cell Response to Biomaterials
Published on: July 8, 2021
Ustilobisorbicillinol A, a Cytotoxic Sorbyl-Containing Aromatic Polyketide from Ustilaginoidea virens
Daowan Lai1, Jiajia Meng1, Xuping Zhang1
1Department of Plant Pathology, College of Plant Protection , China Agricultural University , Beijing 100193 , China.
Abstract:
Ustilobisorbicillinol A (1), which is a novel bisorbicillinoid featuring a unique cage structure that incorporates one sorbicillinol and one sorbyl-containing phenanthrenone unit, was isolated from the culture of Ustilaginoidea virens. Three biogenetically related new metabolites (2-4) were also isolated. Their structures were elucidated by extensive spectroscopic analyses, including the 13C NMR and electronic circular dichroism (ECD) calculations for the configurational assignment. The biosynthetic pathway for these sorbyl-containing polyketides was proposed. Compound 1 showed pronounced cytotoxicity, and it induced significant cell cycle arrest and apoptosis.
Related Concept Videos
Nucleophilic Aromatic Substitution of Aryldiazonium Salts: Aromatic SN1
In the Sandmeyer reaction, for example, the diazonio group is replaced by a chloro, bromo,...
Aromatic Compounds: Overview
In 1825, Faraday isolated...
Basicity of Aromatic Amines
Nomenclature of Aromatic Compounds with a Single Substituent
Five-Membered Heterocyclic Aromatic Compounds: Overview
Nucleophilic Aromatic Substitution: Addition–Elimination (SNAr)
The reaction begins with an attack of the nucleophile on the carbon that holds the leaving group. This results in the delocalization of the π electrons over the ring carbons. The resonance interaction between...

