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Updated: Jan 28, 2026

Rapid One-step Enzymatic Synthesis and All-aqueous Purification of Trehalose Analogues
Published on: February 17, 2017
A concise synthesis and biological study of evodiamine and its analogues
Jie-Dan Deng1, Shuai Lei, Yi Jiang
1School of Pharmacy, Lanzhou University, West Donggang Road, No. 199, Lanzhou 730000, China. tanwen@lzu.edu.cn zhenw@lzu.edu.cn.
Abstract:
Efficient access to evodiamine and its analogues is presented via Lewis acid catalysis. In this reaction, three chemical bonds and two heterocyclic-fused rings are constructed in one step. The reaction shows good functional group tolerance and atom economy, and various heteroatom-containing evodiamine analogues are obtained in moderate to excellent yields even on a gram scale. An anti-tumor study in vitro demonstrates compound 2b possesses potent efficacy against hepatoma cell line (IC50 = 5.7 μM).
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