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Updated: Jan 28, 2026

Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation
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High-definition blood flow imaging in the assessment of left ventricular function: Initial experience and comparison

Geru Wu1, Tianrong Xie1, Meneleo M Dimaano1

  • 1Division of Cardiology, Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas.

Echocardiography (Mount Kisco, N.Y.)
|February 21, 2019
PubMed

Insights

High-definition blood flow imaging (HD-Flow) accurately assesses left ventricular (LV) function, improving endocardial visualization similarly to contrast echocardiography but with faster acquisition times. This novel technique is user-friendly for LV function evaluation.

Area of Science:

  • Cardiovascular Imaging
  • Echocardiography
  • Ultrasound Technology

Background:

  • Contrast echocardiography enhances left ventricular (LV) function assessment by improving endocardial border visualization.
  • High-definition blood flow imaging (HD-Flow) is a novel ultrasound technique designed to improve LV blood flow discrimination and endocardial border definition without contrast.

Purpose of the Study:

  • To evaluate the accuracy and reproducibility of HD-Flow in assessing LV function.
  • To compare HD-Flow with contrast echocardiography for LV function parameters.

Main Methods:

  • Eighty patients with technically limited echocardiograms underwent sequential HD-Flow and contrast imaging.
  • Comparison included LV endocardial visualization, image acquisition time, wall motion, volumes, ejection fraction (EF), stroke volume (SV), and stroke volume index (SVI).
  • Inter- and intra-observer agreement was assessed in a subgroup.

Main Results:

  • Both HD-Flow and contrast significantly improved endocardial border definition compared to baseline (94.1% and 94.9% vs. 71%).
  • HD-Flow acquisition time was significantly shorter than contrast (2.13 min vs. 10.96 min).
  • Measurements of LV volumes, EF, SV, and SVI showed good correlation between HD-Flow and contrast, though HD-Flow slightly underestimated volumes.

Conclusions:

  • HD-Flow is a feasible and user-friendly technique for enhancing LV endocardial definition.
  • HD-Flow is effective for both qualitative and quantitative assessment of LV function, offering a faster alternative to contrast echocardiography.
Abstract

Keywords:
HD-Flow echocardiographycontrast echocardiographyendocardial border definitionleft ventricular function

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