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NCCN Guidelines Insights: Breast Cancer, Version 3.2018.
Matthew P Goetz1, William J Gradishar2, Benjamin O Anderson3
11Mayo Clinic Cancer Center.
Journal of the National Comprehensive Cancer Network : JNCCN
|February 22, 2019
Summary
Updated NCCN Guidelines Insights provide recommendations for multigene assays in adjuvant chemotherapy decisions for hormone receptor-positive, HER2-negative early-stage breast cancer. These insights summarize key updates and their rationale.
Area of Science:
- Oncology
- Genomics
- Clinical Guidelines
Background:
- Hormone receptor-positive (HR+), HER2-negative early-stage invasive breast cancer represents a significant patient population.
- Adjuvant systemic chemotherapy decisions require careful consideration of individual patient risk and tumor biology.
- Multigene assays offer valuable prognostic and predictive information.
Purpose of the Study:
- To summarize the updated National Comprehensive Cancer Network (NCCN) Guidelines Insights.
- To highlight recommendations for using multigene assays in treatment decisions.
- To discuss the rationale supporting these updated recommendations.
Main Methods:
- Review of the latest NCCN Guidelines Insights.
- Analysis of recommendations concerning multigene assays.
- Synthesis of the evidence and expert consensus informing the updates.
Main Results:
- Updated recommendations for the application of multigene assays in HR+, HER2-negative early-stage breast cancer.
- Guidance on interpreting assay results to inform adjuvant chemotherapy decisions.
- Emphasis on personalized treatment strategies based on genomic profiling.
Conclusions:
- Multigene assays are integral to personalized treatment planning for HR+, HER2-negative early breast cancer.
- Updated NCCN guidelines provide a framework for optimizing chemotherapy use.
- These insights aim to improve patient outcomes through evidence-based recommendations.
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