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Updated: Jan 28, 2026

Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives
Published on: September 16, 2021
Knowledge about Age-Related Decline in Fertility and Oocyte Cryopreservation: A National Survey
Karissa C Hammer1, Alyssa N Kahan1, Louis F Fogg1
1Department of Obstetrics and Gynecology, Rush University Medical Center, Chicago, IL, USA.
Context:
Women worldwide are delaying childbearing, but are they aware of the age-related decline in fertility?
Aims:
The aim of this study is to investigate awareness of age-related decline in fertility and oocyte cryopreservation.
Settings And Design:
A primary analysis of a cross-sectional electronic survey with a nationally representative sample of nulliparous women aged 25-45 years.
Subjects And Methods:
A national online survey performed March 4-March 9, 2016.
Statistical Analysis Used:
A linear regression model and ANOVA tests were performed.
Results:
A total of 1213 women completed the survey. A significant difference was discovered in fecundity knowledge between women who identified as in a partnership compared to those who did not. Partnered women were more likely to respond "know a lot" about the age-related decline in fertility, whereas unpartnered women were more likely to respond "never heard of it" (P < 0.01). Partnered women are also more likely to respond that they would have made different life choices had they been more knowledgeable about fertility at a younger age (P = 0.01). The majority of the survey population had heard of oocyte cryopreservation but did not know much about it.
Conclusions:
Slightly over half of participants had an understanding of the natural age-related decline in fertility. Having a partner significantly increased the likelihood that a woman reported more knowledge about fertility. More effort is necessary to educate all women on assisted reproductive technologies and the natural age-related decline in fertility, specifically single women of childbearing age.
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