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Updated: Jan 28, 2026

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Zebrafish Model of Neuroblastoma Metastasis
Published on: March 14, 2021
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LncRNAs join hands together to regulate neuroblastoma progression
Tanmoy Mondal1, Chandrasekhar Kanduri1
1Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Molecular & Cellular Oncology
|February 22, 2019
Summary
Single nucleotide polymorphisms linked to neuroblastoma risk interact with long noncoding RNAs (lncRNAs). These lncRNAs, CASC15 and NBAT1, cooperate to control neuroblastoma progression by regulating a key gene axis.
Area of Science:
- Genetics
- Molecular Biology
- Cancer Research
Background:
- Single nucleotide polymorphisms (SNPs) associated with traits often overlap with noncoding transcripts.
- The functional contribution of these overlapping noncoding transcripts to disease phenotypes remains under-investigated.
- Neuroblastoma is a pediatric cancer with complex genetic underpinnings.
Purpose of the Study:
- To investigate the role of long noncoding RNAs (lncRNAs) at the 6p22.3 neuroblastoma risk locus.
- To elucidate the functional cooperation between sense-antisense lncRNAs in neuroblastoma progression.
- To identify the regulatory axis controlled by these lncRNAs in neuroblastoma.
Main Methods:
- Analysis of lncRNAs at the 6p22.3 locus.
- Functional studies on lncRNA cooperation (CASC15 and NBAT1).
- Investigation of the SOX9-CHD7-USP36 regulatory axis.
Main Results:
- Identified functional cooperation between sense-antisense lncRNAs CASC15 and NBAT1 at the 6p22.3 locus.
- Demonstrated that CASC15 and NBAT1 control neuroblastoma progression.
- Showed that these lncRNAs regulate the SOX9-CHD7-USP36 regulatory axis.
Conclusions:
- lncRNAs CASC15 and NBAT1 play a critical role in neuroblastoma progression.
- Functional cooperation between sense and antisense lncRNAs is a key mechanism in controlling cancer development.
- The SOX9-CHD7-USP36 axis is a crucial target regulated by lncRNAs in neuroblastoma.
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