Related Experiment Video

Updated: Jan 28, 2026

Rescue and Characterization of Recombinant Virus from a New World Zika Virus Infectious Clone
07:35

Rescue and Characterization of Recombinant Virus from a New World Zika Virus Infectious Clone

Published on: June 7, 2017

10.2K

Histopathologic Changes in Placental Tissue Associated With Vertical Transmission of Zika Virus

Geovane R Santos, Clóvis A L Pinto, Raphael C S Prudente

    International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists
    |February 22, 2019
    PubMed

    Zika virus (ZIKV) is highly neurotropic after crossing the placenta, inducing teratogenic effects that result in delayed development and microcephaly in infants. The available evidence for vertical transmission of this infection is based on placental studies showing alterations in trophoblastic tissue. However, complete characterization of ZIKV-infected placenta and involved pathways has yet to be fully clarified. This case report of placental ZIKV infection describes morphologic and molecular changes in the placenta. Hyperplasia of placental Hofbauer cells in chorionic villi and numerous histiocyte-like cells in the decidua were observed. The decidua, fibroblasts, and chorion, as well as circulating cells in the intravascular compartment stained positive for ZIKV envelop protein. Deciduitis was present on the maternal surface of the placenta, with a prevalence of lymphocytes associated with vasculitis. A high level of uncommitted CD3 T lymphocytes were present, in addition to CD4 and CD8 cells. Elevated expression of the apoptosis inhibitor, Bcl-2, was observed in syncytiotrophoblasts. These parameters may promote the persistence of ZIKV in placental tissue and transmission to the fetus.

    More Related Videos

    Vector Competence Analyses on Aedes aegypti Mosquitoes using Zika Virus10:35

    Vector Competence Analyses on Aedes aegypti Mosquitoes using Zika Virus

    Published on: May 31, 2020

    3.5K
    Zika Virus Specific Diagnostic Epitope Discovery11:37

    Zika Virus Specific Diagnostic Epitope Discovery

    Published on: December 12, 2017

    8.3K

    Related Concept Videos

    Gonadal and Placental Hormones01:24

    Gonadal and Placental Hormones

    The gonads, namely the testes in males and the ovaries in females, are pivotal in producing gonadal hormones that orchestrate the intricate processes of sexual development and reproduction.
    In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair...
    3.1K
    Vertical Curve: Problem Solving01:23

    Vertical Curve: Problem Solving

    Vertical curves provide the transition between two roadway grades, ensuring safety, comfort, and functionality. Calculating elevations at specific stations along the curve involves several systematic steps based on the curve's geometry and provided design parameters.The vertical curve is defined by its length, grades, Point of Vertical Intersection (P.V.I.) location, and P.V.I. elevation. The stations of the Point of Vertical Curvature (P.V.C.), where the curve begins, and the Point of Vertical...
    487
    What are Viruses?00:50

    What are Viruses?

    Overview
    128.0K
    Introduction to Vertical Curves01:24

    Introduction to Vertical Curves

    Vertical curves are parabolic transitions that connect different grades on highways and railroads, ensuring a smooth alignment between back and forward tangents. The back tangent represents the initial grade, while the forward tangent defines the subsequent grade. These curves can be symmetrical, with equal tangent lengths, or nonsymmetrical, with varying lengths. The key points defining a vertical curve include the Point of Vertical Intersection (P.V.I.), where the tangents meet; the Point of...
    582
    Elevation of Intermediate Points on Vertical Curves01:20

    Elevation of Intermediate Points on Vertical Curves

    Vertical curves are essential in roadway design because they provide smooth transitions between varying roadway grades. Designing vertical curves involves calculating intermediate elevations and identifying the curve's highest or lowest point, which is essential for optimal roadway performance.Intermediate elevations on a vertical curve are determined using the tangent offset method. This method considers the initial elevation at the start of the curve, the grades, and the curve's geometry. The...
    285
    Sight Distance in a Vertical Curve01:29

    Sight Distance in a Vertical Curve

    Sight distance on vertical curves is critical in roadway design. It ensures drivers can see far enough ahead to identify and respond to hazards effectively. This directly impacts safety, driver comfort, and the overall efficiency of the transportation network.Vertical curves are classified into crest and sag curves based on their geometry. For crest curves, sight distance is determined by the line of sight between a driver's eye and a small object on the road's surface. Design parameters for...
    364