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Visit-to-visit blood pressure variability and hip fracture risk in older persons

T-C Li1,2, C-I Li3,4, C-S Liu3,4,5

  • 1Department of Public Health, College of Public Health, China Medical University, Taichung, Taiwan.

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
|February 22, 2019
PubMed

Insights

Blood pressure variability, measured by systolic blood pressure coefficient of variation (SBP-CV), predicts hip fracture risk in older adults with type 2 diabetes. Maintaining stable blood pressure may reduce fracture incidence.

Area of Science:

  • Gerontology
  • Endocrinology
  • Cardiovascular Medicine

Background:

  • Hypertension is a known risk factor for osteoporosis and hip fractures.
  • Limited research exists on blood pressure variability (BPV) as a predictor of hip fracture in older adults with diabetes.

Purpose of the Study:

  • To investigate the association between blood pressure variability (BPV), specifically the coefficient of variation (CV) of blood pressure, and hip fracture incidence in older individuals with type 2 diabetes.

Main Methods:

  • A retrospective cohort study involving 21,160 patients with type 2 diabetes (age ≥ 50 years) from Taiwan's National Diabetes Care Management Program.
  • Analyzed 1-year variability in systolic blood pressure (SBP-CV) and diastolic blood pressure (DBP-CV) at baseline and hip fracture incidence over 8.2 years.

Main Results:

  • A total of 937 incident hip fractures were recorded.
  • After multivariate adjustment, higher SBP-CV (third tertile) was associated with an increased risk of hip fracture (HR 1.18; 95% CI 1.00-1.40) compared to the lowest tertile.
  • DBP-CV did not show a significant association with hip fracture risk.

Conclusions:

  • Systolic blood pressure stability, indicated by lower SBP-CV, is a significant predictor of reduced hip fracture incidence in older adults with type 2 diabetes.
  • These findings highlight the importance of monitoring and managing blood pressure variability in this patient population.

Keywords:
Blood pressureDiabetesHip fracture

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