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A VCSEL-Based NIR Transillumination System for Morpho-Functional Imaging.

Sabina Merlo1, Valentina Bello2, Elisabetta Bodo3

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Summary
This summary is machine-generated.

This study presents a portable device for non-invasive tissue imaging using near-infrared lasers. It captures morphological images and detects physiological parameters like heart rate in living samples up to 5 cm thick.

Keywords:
VCSELnear infrared radiationnon-invasive morpho-functional imagingnon-ionizing radiationtissue imagingtransillumination

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Area of Science:

  • Biomedical Optics
  • Medical Imaging
  • Ophthalmology

Background:

  • Transillumination is a fundamental technique for assessing internal tissue structures.
  • Limitations include low-resolution imaging due to light scattering.
  • Need for portable, non-invasive methods for in vivo diagnostics.

Purpose of the Study:

  • To develop a portable optoelectronic system for efficient transillumination and imaging of in vivo samples.
  • To demonstrate the system's capability for morphological and functional analysis.
  • To enable imaging in ambient daylight for practical applications.

Main Methods:

  • Utilized a matrix of 36 near-infrared Vertical Cavity Surface Emitting Lasers (VCSELs) for tissue illumination.
  • Employed a custom low-voltage current driver for the laser source.
  • Used a monochrome Complementary Metal Oxide Semiconductor (CMOS) camera with narrow-band optical filtering for detection.

Main Results:

  • Successfully acquired morphological images of the hand dorsal vein pattern.
  • Achieved non-invasive functional detection of physiological parameters, including breath and heart rate.
  • Demonstrated effective imaging of in vivo samples up to 5 cm thick.

Conclusions:

  • The developed portable system enables efficient transillumination and imaging of macroscopic structures.
  • The system can simultaneously provide morphological and functional information from living tissues.
  • This technology offers a promising non-invasive tool for in vivo diagnostics and monitoring.