[The use of ofloxacin in otorhinolaryngology]

Continuing development of antimicrobial resistance highlights the need for new antimicrobial agents. Despite many new molecules there is still a need for effective oral compounds. The fluoroquinolones are a new group of antibiotics with a wide spectrum of antibacterial activity which includes resistant strains and difficult microorganisms as Pseudomonas aeruginosa. Ofloxacin is a fluoroquinolone available for oral use showing good absorption with high blood levels and quite satisfactory tissue, penetration particularly in O.R.L. district. The treatment, consisting of ofloxacin 200 mg twice daily, of several patient (including two cases of rhinitis) was both safe and effective.