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Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells
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FGF23 and Fetuin-A Interaction and Mesenchymal Osteogenic Transformation

Deborah Mattinzoli1, Masami Ikehata2, Koji Tsugawa3

  • 1Renal Research Laboratory Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy. deborah.mattinzoli@policlinico.mi.it.

International Journal of Molecular Sciences
|February 23, 2019
PubMed
Summary

Mesenchymal stem cells produce Fibroblast growth factor 23 (FGF23), which drives Fetuin-A production. This FGF23-Fetuin-A interaction in bone marrow suggests a role in osteoblast differentiation and mineral bone disorders.

Keywords:
FGF23Fetuin-A promoterchronic kidney diseasemesenchymal cellosteogenesis

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