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Updated: Jan 28, 2026

Practical Use of RNA Interference: Oral Delivery of Double-stranded RNA in Liposome Carriers for Cockroaches
Published on: May 1, 2018
Neurodegeneration, Heterochromatin, and Double-Stranded RNA
Tassa K Saldi1, Patrick K Gonzales2, Thomas J LaRocca2
1Department of Biochemistry and Molecular Genetics, University of Colorado, Aurora, CO, USA.
Abstract:
Changes in chromatin and epigenetic modifications have been associated with aging and aging-associated neurodegenerative diseases, although the causal relationship between these changes and disease-related pathology has been unclear. Recent studies have now made direct connections between neurodegeneration-associated proteins and derepression of repetitive element transcription due to changes in heterochromatin. We suggest that this derepression leads to an increased accumulation of intracellular double-stranded RNA (dsRNA), with an attendant induction of innate immune responses that contribute to the neuroinflammation found in essentially all age-associated neurodegenerative diseases.
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