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Acute coagulation disorder in a critically ill patient - A case report

Agnes Oberhuber1, Benedikt Treml1, Dietmar Fries1

  • 1Department of General and Surgical Critical Care Medicine, Medical University Innsbruck, Innsbruck, Austria.

Journal of the Intensive Care Society
|February 23, 2019
PubMed

A 79-year-old critically ill woman presented with remarkable prolongation of activated partial thromboplastin time and thrombin time combined with high levels of anti-factor IIa activity 26 days after coronary artery bypass grafting. Coagulation disorder was associated with severe bleeding. Cause of coagulopathy was accidental administration of argatroban in an unknown dosage. Clearance of argatroban was significantly prolonged because of a liver function disorder related to septic multiorgan failure. Argatroban reversal was performed with prothrombin complex concentrate.

Keywords:
Coagulationargatrobancoagulopathyintensive carethrombin inhibitor

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