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Acute coagulation disorder in a critically ill patient - A case report
Agnes Oberhuber1, Benedikt Treml1, Dietmar Fries1
1Department of General and Surgical Critical Care Medicine, Medical University Innsbruck, Innsbruck, Austria.
Journal of the Intensive Care Society
|February 23, 2019
Summary
Accidental argatroban administration caused severe bleeding in a critically ill patient due to prolonged drug clearance from liver dysfunction. Prothrombin complex concentrate was used for argatroban reversal, successfully managing the coagulopathy.
Area of Science:
- Cardiology
- Critical Care Medicine
- Hematology
Background:
- Critically ill patients may develop coagulopathies post-cardiac surgery.
- Drug-induced coagulopathy, such as from argatroban, can lead to severe bleeding.
- Liver dysfunction can significantly impair drug clearance, prolonging its effects.
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