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Updated: Jan 28, 2026

Functional Near Infrared Spectroscopy of the Sensory and Motor Brain Regions with Simultaneous Kinematic and EMG Monitoring During Motor Tasks
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Motor Cortex Function in Fibromyalgia: A Study by Functional Near-Infrared Spectroscopy.

Eleonora Gentile1, Katia Ricci1, Marianna Delussi1

  • 1Applied Neurophysiology and Pain Unit, SMBNOS Department, Bari Aldo Moro University, Polyclinic General Hospital, Via Amendola 207 A, 70123 Bari, Italy.

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Summary
This summary is machine-generated.

Fibromyalgia patients show slower motor speed and reduced motor cortex oxygenation during fast movements. This motor cortex dysfunction supports therapies modulating brain activity in fibromyalgia.

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Area of Science:

  • Neuroscience
  • Medical Imaging
  • Human Physiology

Background:

  • Fibromyalgia (FM) is associated with altered motor cortex excitability.
  • Transcranial stimulation techniques have shown positive results in FM patients.
  • Understanding motor cortex metabolism in FM is crucial for targeted therapies.

Purpose of the Study:

  • To investigate motor cortex metabolism in fibromyalgia patients during rest and motor tasks.
  • To compare metabolic activity between FM patients and healthy controls using functional Near-Infrared Spectroscopy (fNIRS).
  • To determine if motor cortex dysfunction correlates with FM severity or duration.

Main Methods:

  • Functional Near-Infrared Spectroscopy (fNIRS) was used to monitor cortical tissue metabolism in real-time.
  • 24 fibromyalgia patients and 24 healthy subjects participated in the study.
  • Participants performed resting state, slow, and fast finger tapping tasks.

Main Results:

  • Fibromyalgia patients exhibited significantly slower motor speed compared to controls.
  • No significant differences in motor area metabolism were observed during resting state and slow movements.
  • FM patients showed significantly lower oxyhemoglobin concentrations during fast finger tapping compared to controls.
  • This metabolic abnormality was independent of FM severity and duration.

Conclusions:

  • Motor cortex activation is dysfunctional in fibromyalgia patients, particularly during demanding motor tasks.
  • Reduced oxygenation in motor areas during fast movements suggests impaired metabolic response.
  • These findings support the therapeutic potential of motor cortex modulation for fibromyalgia.