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Related Concept Videos

Nuclear Fusion02:45

Nuclear Fusion

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The process of converting very light nuclei into heavier nuclei is also accompanied by the conversion of mass into large amounts of energy, a process called fusion. The principal source of energy in the sun is a net fusion reaction in which four hydrogen nuclei fuse and ultimately produce one helium nucleus and two positrons.
A helium nucleus has a mass that is 0.7% less than that of four hydrogen nuclei; this lost mass is converted into energy during the fusion. This reaction produces about...
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The Mitotic Spindle02:27

The Mitotic Spindle

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The mitotic spindle—or spindle apparatus—is a eukaryotic, cytoskeletal structure made up of long protein fibers called microtubules. Formed during cell division, the spindle separates sister chromatids and moves them to opposite ends of a parental cell, where the now individual chromosomes are distributed to two daughter cell nuclei.
The bipolar configuration of the mitotic spindle facilitates chromosomal segregation, preparing the cell for division. One mechanism that ensures...
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Spindle Assembly02:50

Spindle Assembly

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Spindle assembly occurs through three, often coexisting, pathways – the centrosome-mediated pathway, the chromatin-mediated pathway, and the microtubule-mediated pathway – collectively contributing to form a robust spindle apparatus.
In most cells, centrosomes are the primary microtubule nucleation centers. In the centrosome-mediated pathway, the G2-prophase transition triggers centrosome maturation and increased microtubule nucleation. Progressive nucleation results in a...
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Transcription01:10

Transcription

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Overview
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
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Transcription Factors02:16

Transcription Factors

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Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
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The Spindle Assembly Checkpoint02:19

The Spindle Assembly Checkpoint

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The spindle assembly checkpoint is a molecular surveillance mechanism ensuring the fidelity of chromosome segregation during anaphase. The checkpoint monitors the completion of all the prerequisite steps before chromosome segregation to determine whether the segregation process should proceed or be delayed.
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Related Experiment Video

Updated: Jan 28, 2026

A Blood-based Test for the Detection of ROS1 and RET Fusion Transcripts from Circulating Ribonucleic Acid Using Digital Polymerase Chain Reaction
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A Blood-based Test for the Detection of ROS1 and RET Fusion Transcripts from Circulating Ribonucleic Acid Using Digital Polymerase Chain Reaction

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Spindle cell liposarcoma with a TRIO-TERT fusion transcript.

David I Suster1, Vikram Deshpande1, Ivan Chebib1

  • 1Massachusetts General Hospital, Department of Pathology, Harvard Medical School, Warren 2, 55 Fruit Street, Boston, MA, 02214, USA.

Virchows Archiv : an International Journal of Pathology
|February 23, 2019
PubMed
Summary

This study identifies a rare liposarcoma with spindle cell features harboring a TRIO-TERT fusion transcript. This finding expands the known genetic landscape of liposarcomas and highlights novel diagnostic markers.

Keywords:
Fusion transcriptLiposarcomaTRIO-TERT

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Related Experiment Videos

Last Updated: Jan 28, 2026

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Area of Science:

  • Oncology
  • Molecular Pathology
  • Genetics

Background:

  • Well-differentiated, dedifferentiated, and myxoid liposarcomas typically exhibit specific genetic alterations like MDM2/CDK4 amplification or FUS-DDIT3 rearrangements.
  • TRIO-TERT fusion genes have recently been identified in various non-translocation-related sarcomas, leading to elevated telomerase activation.

Observation:

  • This report details an unusual liposarcoma case presenting with spindle cell morphology.
  • Next-generation sequencing revealed the presence of a TRIO-TERT fusion transcript in this liposarcoma.

Findings:

  • The identified TRIO-TERT fusion transcript is a novel genetic finding in this specific type of liposarcoma.
  • This fusion is associated with significantly increased TERT mRNA expression and telomerase activation.

Implications:

  • The discovery of TRIO-TERT fusions in liposarcomas broadens the spectrum of sarcomas associated with this genetic event.
  • This finding may lead to new diagnostic and potentially therapeutic strategies for liposarcoma subtypes.