[How I explore... a suspicion of paracetamol allergy in children]

Paracetamol (acetaminophen) is a molecule recognized worldwide for its anti-inflammatory and analgesic properties. While side effects are rare, some patients have allergic or non-allergic hypersensitivity to this molecule. Anamnesis helps to guide the diagnosis. The sensitivity and specificity of the specific IgE assay for paracetamol, skin tests and other in vitro challenge tests have been poorly studied. The oral provocation test remains the gold standard to confirm the diagnosis. In case of confirmed hypersensitivity to paracetamol, it is important to search for an alternative treatment. In this article, we describe a clinical case and its management.