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Endothelial dysfunction in pregnancy metabolic disorders.

Cesar Echeverria1, Felipe Eltit2, Juan F Santibanez3

  • 1Facultad de Medicina, Universidad de Atacama, Copayapu 485, 1531772 Copiapo, Chile.

Biochimica Et Biophysica Acta. Molecular Basis of Disease
|February 23, 2019
PubMed
Summary
This summary is machine-generated.

Endothelial dysfunction is central to metabolic pregnancy disorders like gestational diabetes and hypertension. This review details how endothelial cells lose function, impacting pregnancy health.

Keywords:
Endothelial dysfunctionMetabolic disordersPregnancyReceptorsTransporters

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Area of Science:

  • Obstetrics and Gynecology
  • Vascular Biology
  • Endocrinology

Background:

  • The vascular endothelium is crucial for maintaining metabolic homeostasis during pregnancy.
  • Metabolic disorders in pregnancy, including gestational diabetes, hypertensive disorders, and obesity with hyperlipidemia, are linked to endothelial dysfunction.
  • Endothelial cells, normally responsive to metabolic changes, become dysfunctional in pathological pregnancies.

Purpose of the Study:

  • To review the role of endothelial dysfunction in major metabolic disorders of pregnancy.
  • To describe organ, histological, and cellular changes associated with endothelial dysfunction.
  • To elucidate the molecular mechanisms and cellular signaling pathways involved.

Main Methods:

  • Literature review focusing on endothelial dysfunction in pregnancy metabolic disorders.
  • Analysis of organ, histological, and cellular characteristics.
  • Examination of molecular mechanisms and signaling pathways.

Main Results:

  • Endothelial dysfunction is a common feature in gestational diabetes, hypertensive disorders, and obesity/hyperlipidemia during pregnancy.
  • Specific histological and cellular alterations in endothelial cells are observed in these conditions.
  • Key molecular pathways mediating endothelial responses in pathological pregnancies have been identified.

Conclusions:

  • Endothelial dysfunction is a critical factor in the pathogenesis of common metabolic pregnancy disorders.
  • Understanding these mechanisms offers potential targets for therapeutic interventions.
  • Further research into endothelial cell signaling is vital for improving maternal and fetal outcomes.