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Dynamic Adhesion Assay for the Functional Analysis of Anti-adhesion Therapies in Inflammatory Bowel Disease
Published on: September 20, 2018
Diverse lignans with anti-inflammatory activity from Urceola rosea
Dou-Dou Dong1, Heng Li2, Kun Jiang3
1School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Department of Natural medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Abstract:
Seventeen structurally diverse lignans, comprising six new compounds, ecdysanols A (1), B (11), C - E (13-15), and F (17), were isolated from the caulis of Urceola rosea. The structures and absolute configurations of these new compounds were elucidated by means of extensive analysis of mass and NMR data, as well as chiroptical properties. A bioassay in vitro showed that all lignans possessed anti-inflammatory effects by inhibiting the production of TNF-α, NO and/or IL-6 in LPS-stimulated RAW264.7 cells. Ecdysanol F (17) showed the most strongly effect against NO and IL-6 levels.
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