[Congenital deficiency of humoral and cellular immunity]

The study involves 10 children with primary immunologic deficiency of the humoral and cellular immunity diagnosed on the basis of the clinical symptoms of the disease and immunologic investigation. In 7 children, out of whome three were infants, suffering of recurrent respiratory tract infections, examinations revealed either absence or deficiency of the IgA in the serum and saliva. 2 children presented a classical picture of the Wiskott-Aldrich's syndrome followed by eczema, recurrent infections and trombocytopenia. Having studied the immunologic status in these two children in vitro and in vivo, the authors established deficiency in the humoral and cellular immunity. In an infant aged three months, with diagnosed histiocytosis X after histologic examination of the skin, the authors had examined the function of the T and B cells after which it was concluded that it was a case of rare form of the combined primary immunodeficiency.