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Peculiarities of antibiotic-associated diarrhea development in children with acute respiratory infections
Sergii V Popov1, Oleksandr I Smyian1, Andrii N Loboda1
1Sumy State University, Department of Pediatrics, Sumy, Ukraine
Insights
Antibiotic-associated diarrhea (AAD) affects over half of children with acute respiratory infections (ARI). Key risk factors include limited breastfeeding, gastrointestinal issues, allergies, and parental health habits.
Area of Science:
- Pediatrics
- Infectious Diseases
- Gastroenterology
Background:
- Acute respiratory infections (ARI) are a leading cause of childhood illness globally.
- Antibiotic administration for ARI carries the risk of side effects, including antibiotic-associated diarrhea (AAD).
Purpose of the Study:
- To determine the prevalence of AAD in children with ARI.
- To identify factors influencing the development of AAD in this pediatric population.
Main Methods:
- A study involving 75 children aged 1-12 years diagnosed with ARI and treated with antibiotics.
- Analysis of children's medical history, parental health, and odds ratios (OR) to assess AAD risk factors.
Main Results:
- Overall AAD incidence was 52%, highest (59.3%) in children under 3 years.
- Amoxicillin treatment was associated with 92% of AAD cases.
- Significant risk factors included breastfeeding <6 months (OR 7.65), preterm birth (OR 2.9), and parental factors like age >35 (OR 5.03) and smoking (OR 2.43).
Conclusions:
- Breastfeeding duration, infant's gastrointestinal and allergic history are critical for AAD development.
- Parental health, including gastrointestinal disorders, allergies, and smoking, significantly increases AAD risk in children treated for ARI.
Objective:
Introduction: Acute respiratory infections (ARI) are the main cause of morbidity in most countries. The probability of complications and age determine antibiotics administration. Antibiotic associated diarrhea (AAD) is one of the side effects of antibiotics. The aim: The study of the prevalence rate of AAD and the characteristics of its development in children with ARI.
Patients And Methods:
Materials and methods: The study included 75 children aged from 1 to 12 y diagnosed with ARI, who were treated with age-specific doses of antibiotics. The influence of children's anamnesis, parents' health on the development of AAD was studied with odds ratio calculation (OR).
Results:
Results: In general, AAD incidence was 52%. The highest frequency 59.3% was observed in children under 3 y. AAD most often developed in children treated with amoxicillin - 92%. The greatest dependence of AAD development was connected with breastfeeding less than 6 months - OR was 7.65, preterm birth - 2.9, functional GIT disorders in anamnesis - up to 3.14, allergy - 2.33. The risk of AAD development increased with the age of parents more than 35 y - 5.03, at the age of parents less than 18 and older than 35 y - 4.09, parents' allergies - 3.74 and parents smoking - 2.43.
Conclusion:
Conclusions: The most important factors of AAD development on antibiotics therapy in children with ARI are breastfeeding less than 6 months, functional GIT disorders and allergic conditions in anamnesis. Suboptimal age and parents' health (GIT disorders, allergic conditions and unhealthy habits) also increase the risk of AAD development.
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