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Optimization of the treatment of rotavirus infection in children by using bacillus clausii

Oleksandr I Smiyan1, Kateryna O Smiian-Horbunova1, Tetiana P Bynda1

  • 1Sumy State University, Sumy, Ukraine.

Wiadomosci Lekarskie (Warsaw, Poland : 1960)
|August 10, 2019
PubMed

Insights

Bacillus clausii supplementation improved treatment outcomes for children with rotavirus infection. This probiotic normalized immunoglobulin levels, enhancing the humoral immune system during recovery.

Area of Science:

  • Pediatrics
  • Immunology
  • Microbiology

Background:

  • Rotavirus infection is a primary cause of acute intestinal infections in children globally.
  • Severe rotavirus infection necessitates hospitalization for millions of children annually.
  • Current treatment protocols for rotavirus infection can be optimized.

Purpose of the Study:

  • To evaluate the efficacy of Bacillus clausii in optimizing rotavirus infection treatment in children.
  • To assess the impact of Bacillus clausii on the humoral immune system during rotavirus infection recovery.

Main Methods:

  • A study involving 65 children diagnosed with rotavirus infection.
  • Humoral immunity assessed by measuring serum immunoglobulins (IgG, IgM, IgA) and secretory IgA (sIgA) in coprofiltrate.
  • Children received either standard treatment or standard treatment plus Bacillus clausii.

Main Results:

  • Children receiving Bacillus clausii showed significant symptom reduction compared to standard treatment (p <0.001).
  • Rotavirus infection acutely decreased IgA and increased IgM serum levels, and decreased sIgA in coprofiltrate.
  • Bacillus clausii treatment normalized serum immunoglobulins (IgA, IgM, IgG) and coprofiltrate sIgA during convalescence, unlike standard treatment alone.

Conclusions:

  • Bacillus clausii demonstrates a beneficial effect on the humoral immune system in pediatric rotavirus infection.
  • Supplementation with Bacillus clausii aids in restoring immune balance post-rotavirus infection.
  • This probiotic offers a promising adjunctive therapy for rotavirus infection in children.
Abstract

Keywords:
IgAIgGIgMchildrenhumoral immunityrotavirussIgA

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