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Nanohybrids - cancer theranostics for tiny tumor clusters.

Ramya Dhandapani1, Swaminathan Sethuraman1, Anuradha Subramanian1

  • 1Centre for Nanotechnology and Advanced Biomaterials, SASTRA Deemed University, Thanjavur 613401, India.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|February 24, 2019
PubMed
Summary

This review explores smart nanomedicine strategies to target circulating tumor cells (CTCs), aiming to halt cancer metastasis. Engineering hybrid nanostructures using the RSSR approach offers a novel theranostic solution for improved patient survival.

Keywords:
CancerCirculating tumor clustersHybridNanotheranostics

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Area of Science:

  • Oncology
  • Nanomedicine
  • Theranostics

Background:

  • Cancer nanomedicine advancements enable smart theranostics for heterogeneous cancers.
  • Multifunctional nanostructures are crucial for targeting circulating tumor clusters (CTCs).

Purpose of the Study:

  • To review strategies for engineering smart hybrid nanostructures targeting CTCs.
  • To address the challenge of rapid elimination of aggressive, metastatic tumor cell clusters.
  • To provide insight into the RSSR (Retention, Stealth, Sticky, and Release) strategy.

Main Methods:

  • Exploration of geometrical anisotropy and supramolecular nanoarchitecture in nanostructure design.
  • Integration of multiplex functionalities for multi-modal drug delivery systems.
  • Focus on engineering hybrid nanostructures for CTC targeting.

Main Results:

  • Development of integrated multi-modal drug delivery systems for CTCs.
  • Potential for intelligent theranostic systems to control primary tumor progression and invasion.
  • Highlighting the RSSR strategy for enhanced nanostructure performance.

Conclusions:

  • Targeting CTCs with advanced nanostructures can terminate the metastatic cascade.
  • The RSSR strategy offers a promising approach for developing smart hybrid nanostructures.
  • This theranostic approach holds potential to increase patient survival rates by preventing secondary niche formation.