Related Experiment Video
Updated: Jan 7, 2026
08:28
A Lab-On-A-Chip Platform for Stimulating Osteocyte Mechanotransduction and Analyzing Functional Outcomes of Bone Remodeling
Published on: May 21, 2020
7.2K
Translating Structural Hierarchy and Mechanobiology of Bone in Microphysiological Systems
Ramya Dhandapani1, Kadambari Sathyanarayanan1, Shantanu Pradhan1
1Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai, India.
Small (Weinheim an Der Bergstrasse, Germany)
|December 31, 2025
Summary
Bone
Area of Science:
- Biomechanical Engineering
- Cellular Mechanobiology
- Tissue Engineering
Background:
- Bone's hierarchical structure integrates mechanical cues for homeostasis.
- Nanoscale (collagen, hydroxyapatite) and microscale (pericellular matrix) components regulate bone mechanics.
- Cancer disrupts bone homeostasis via altered mechanics and signaling.
Purpose of the Study:
- Review mechanobiological crosstalk in bone.
- Highlight microfluidic bone-on-chip platforms for studying bone pathologies.
- Discuss applications in drug screening and pre-clinical research.
Main Methods:
- Literature review of bone mechanobiology.
- Analysis of scale-spanning hierarchical structures in bone.
- Description of microfluidics-based bone-on-chip platforms.
Main Results:
- Mechanobiological crosstalk occurs across multiple scales in bone.
- Cancer disrupts normal bone mechanotransduction and remodeling.
- Bone-on-chip platforms can recapitulate in vivo mechanical stimuli.
Conclusions:
- Understanding bone mechanobiology is crucial for treating pathologies like cancer.
- Microfluidic platforms offer a promising tool for bone disease research and drug screening.
- These platforms can provide predictive pre-clinical data, complementing animal models.
More Related Videos
09:07A Human Bone Marrow 3D Model to Investigate the Dynamics and Interactions Between Resident Cells in Physiological or Tumoral Contexts
Published on: December 16, 2022
3.8K
06:59Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model
Published on: September 8, 2023
3.3K
Related Concept Videos
01:23Bone as Supporting Connective Tissue
6.3K
Bone tissue forms the internal skeleton of vertebrate animals, providing structure to the body.
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts—...
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts—...
6.3K
01:18The Bone Matrix
5.4K
Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...
5.4K
01:40Bone Remodeling
40.2K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
40.2K
01:09Spongy Bone
7.4K
All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
7.4K
01:55Bone Structure
51.4K
Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.
51.4K
01:27Compact Bone
15.9K
Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
15.9K