Three-dimensional drivable optrode array for high-resolution neural stimulations and recordings in multiple brain...

Area of Science:

• Neuroscience
• Biomedical Engineering
• Optogenetics

Background:

• Brain-computer interfaces (BCI) are crucial for neuroscience research and treating neurological disorders.
• Existing BCI devices face challenges in high-density integration and multi-functionality.

Purpose of the Study:

• To develop a 3D drivable optrode array with laser diodes (LDs) coupled waveguides for advanced BCI applications.
• To overcome limitations of fiber tangle and tissue heating in neural probes.

Main Methods:

• Development of a 3D integrated optrode array using LD-coupled waveguides.
• Integration with a 3D printed micro-drive for postoperative position adjustment.
• High-resolution neural stimulation and recording in specific mouse brain regions.

Main Results:

• The novel device achieved 3D integration of optrodes, avoiding fiber tangle and tissue heating.
• Postoperative adjustment of the optrode array was successfully demonstrated.
• High-resolution neural activity was recorded and stimulated in the prelimbic cortex, mediodorsal thalamic nucleus, dorsal medial caudate nucleus, and posterior motor cortex 2.

Conclusions:

• The developed 3D optrode array is a promising tool for investigating complex neural networks.
• This technology facilitates advanced research into working memory and neurological disorders.