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Kaleb Vinehout1, Brian D Schmit1, Sheila Schindler-Ivens2

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|February 26, 2019
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Summary
This summary is machine-generated.

Brain network function differs in stroke survivors. Global connectivity was reduced during pedaling and nonparetic tapping, while local connectivity changes were task-dependent, revealing altered brain networks post-stroke.

Keywords:
fMRIfunctional connectivitylocomotionmotor controlstroketask-based

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Area of Science:

  • Neuroscience
  • Systems Neuroscience
  • Rehabilitation Science

Background:

  • Cortical activation volume is reduced during pedaling and increased during paretic foot tapping in stroke survivors compared to controls.
  • Altered brain network function may explain these observed differences in activation volume.

Purpose of the Study:

  • To investigate task-dependent changes in local and global brain network functional connectivity in individuals with stroke.
  • To determine if differences in brain activation during motor tasks post-stroke are related to altered network function.

Main Methods:

  • Functional magnetic resonance imaging (fMRI) was employed to assess brain network function during pedaling and foot tapping tasks.
  • Independent component analysis (ICA) was used to identify regions of interest (ROIs) including primary sensorimotor cortex (M1S1), anterior lobe of cerebellum (AlCb), and secondary sensory cortex (S2).
  • Global connectivity (inter-ROI correlations) and local connectivity (intra-ROI voxel correlations), along with local efficiency and clustering coefficient, were calculated.

Main Results:

  • Stroke participants exhibited reduced global brain network connectivity compared to controls during pedaling and nonparetic foot tapping, but not during paretic foot tapping.
  • Local network function was elevated during paretic foot tapping and reduced during pedaling in stroke survivors.
  • Connectivity changes were observed in M1S1, AlCb, and S2, with significant task-dependent alterations in both local and global network function.

Conclusions:

  • Brain network function, both local and global, is altered in individuals post-stroke, with changes being task-dependent.
  • Reduced global connectivity may underlie decreased brain activation volume observed during pedaling in stroke survivors.
  • These findings highlight the complex, task-specific neuroplasticity and network reorganization following stroke.