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Related Concept Videos

Uncertainty in Measurement: Accuracy and Precision03:37

Uncertainty in Measurement: Accuracy and Precision

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Scientists typically make repeated measurements of a quantity to ensure the quality of their findings and to evaluate both the precision and the accuracy of their results. Measurements are said to be precise if they yield very similar results when repeated in the same manner. A measurement is considered accurate if it yields a result that is very close to the true or the accepted value. Precise values agree with each other; accurate values agree with a true value. 
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Epilepsy and Seizures: Overview01:24

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Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
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Accuracy and Precision01:52

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Scientists typically make repeated measurements of a quantity to ensure the quality of their findings and to evaluate both the precision and the accuracy of their results. Measurements are said to be precise if they yield very similar results when repeated in the same manner. A measurement is considered accurate if it yields a result that is very close to the true or the accepted value. Precise values agree with each other; accurate values agree with a true value.  Highly accurate...
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Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

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In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
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The Precise Definition of a Limit01:27

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Understanding the formal definition of a limit is essential for precise mathematical analysis. This concept allows us to rigorously determine how a function behaves near a particular point without relying on ambiguous notions such as "getting close." The ε-δ definition plays a foundational role in calculus, ensuring analytical clarity and logical consistency in limit evaluation.The formal definition states that the limit of a function f(x) as x approaches a is L, written asif for...
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Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

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Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
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Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy
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Precision in pediatric epilepsy.

Priya Sharma1, Ammar Hussain1, Robert Greenwood2

  • 1Department of Neurology, University of North Carolina School of Medicine, Physicians Office Building, Chapel Hill, NC, 27599-7025, USA.

F1000Research
|February 26, 2019
PubMed
Summary
This summary is machine-generated.

Pediatric epilepsy diagnosis is advancing with precision medicine, moving beyond seizure type to identify causes and enable targeted treatments for children with epilepsy. New tools aid in pinpointing seizure origins for surgery and defining treatable epilepsy syndromes.

Keywords:
autoimmune encephalitisepilepsy gene panelsmetabolic testingwhole exome sequencingwhole genome sequencing

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Area of Science:

  • Neurology
  • Pediatric Neurology
  • Epileptology

Background:

  • Epilepsy is a common and severe neurological disorder in children.
  • Historically, pediatric epilepsy treatment relied on seizure classification.
  • Limited understanding of underlying causes hindered precise management.

Purpose of the Study:

  • To review advances in diagnosing pediatric epilepsy.
  • To explore new tools for identifying seizure foci for surgical intervention.
  • To define epilepsy syndromes that are amenable to specific treatments.

Main Methods:

  • Utilizing the International League Against Epilepsy's etiological classification system.
  • Reviewing recent diagnostic advancements in pediatric epilepsy.
  • Describing novel techniques for localizing seizure onset zones.

Main Results:

  • The advent of precision medicine is transforming pediatric epilepsy care.
  • New etiological classifications provide a framework for diagnosis.
  • Advanced imaging and testing facilitate precise identification of epilepsy causes and seizure foci.

Conclusions:

  • Precision medicine offers a paradigm shift in pediatric epilepsy management.
  • Accurate etiological diagnosis is crucial for effective treatment strategies.
  • Identifying treatable epilepsy syndromes allows for optimized patient outcomes.