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Updated: Jan 28, 2026

Ischemia-reperfusion Model of Acute Kidney Injury and Post Injury Fibrosis in Mice
Published on: August 9, 2013
[Acute kidney injury related to acute vascular disorders]
Franck Pourcine1, Camille Petit-Hoang1, Vincent Audard1
1Service de néphrologie et transplantation, CHU Henri-Mondor, université Paris-Est Créteil, Créteil, France.
Abstract:
Acute kidney injury related to acute vascular disorders. A broad spectrum of vascular disease characterized by primary vessel involvement may be associated with acute renal failure. These diseases are usually classified according to the size of the injured vessel that include the small vessels (thrombotic microangiopathy, kidney injury due to malignant hypertension, scleroderma renal crisis, and cholesterol crystal embolism disease), the medium vessels (polyarteritis nodosa) or the large size vessels (acute renal infarction). Regardless of the primary pathogenic mechanisms and/or the size of the involved vessels, increased of blood pressure associated with acute kidney injury is a major and common feature of these acute renal disorders. A prompt diagnosis of the vascular disease causing acute kidney damage is required to reduce the risk of morbi-mortality due to renal impairment and to the systemic consequences of the underlying disease and to start an appropriate therapeutic management that should systematically include blood pressure control.
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