Related Experiment Video
Updated: Jan 28, 2026
08:24
Author Spotlight: Exploring the Potential of Massage Therapy in Cerebral Palsy Using Animal Models
Published on: August 11, 2023
2.6K
Tadalafil improves bladder dysfunction and object recognition in rats with pelvic venous congestion
Saori Nishijima1, Kimio Sugaya1, Katsumi Kadekawa1
1Southern Knights' Laboratory, Okinawa, Japan.
Summary
Tadalafil improved bladder function and cognitive abilities in rats with pelvic venous congestion. This treatment enhanced locomotor activity and nitric oxide levels, suggesting therapeutic potential for related conditions.
Area of Science:
- Urology
- Pharmacology
- Neuroscience
Background:
- Pelvic venous congestion in rats leads to urinary frequency, reduced activity, and impaired cognition.
- Nitric oxide (NO) pathways are implicated in bladder function and neurological processes.
- Pelvic venous congestion is associated with decreased NO levels and endothelial NO synthase (eNOS) expression in the bladder.
Purpose of the Study:
- To investigate the therapeutic effects of tadalafil on bladder function and object recognition in a rat model of pelvic venous congestion.
- To assess the impact of tadalafil on locomotor activity, nitric oxide metabolism, and related molecular markers.
Main Methods:
- Female rats underwent pelvic venous congestion induction via vein ligation.
- Tadalafil was administered orally to a subset of congested rats for 4 weeks.
- Evaluations included voiding behavior, locomotor activity, novel object recognition, cystometry, and biochemical/histological analyses.
Main Results:
- Pelvic venous congestion rats exhibited increased urinary frequency, decreased locomotor activity, and impaired object recognition.
- Tadalafil treatment improved locomotor activity, bladder function, and object recognition in congested rats.
- Tadalafil increased plasma and urinary nitric oxide, plasma monoamines, and bladder neuronal nitric oxide synthase (nNOS) expression, with enhanced bladder vascularity.
Conclusions:
- Tadalafil shows promise in ameliorating bladder dysfunction and cognitive deficits associated with pelvic venous congestion.
- The beneficial effects of tadalafil may be mediated by increased blood flow to the bladder and brain, and elevated dopamine levels.
- Tadalafil's impact on NO pathways and vascularity suggests a multi-faceted therapeutic mechanism.
Related Concept Videos
01:04Venous Return
12.2K
The circulatory system plays a crucial role in ensuring the optimal functioning of the human body. One of its critical components is venous return - the process that completes the blood circulation cycle. This article will delve into the concept of venous return, how it works, and its significance to our health.
What is Venous Return?
Venous return refers to the rate at which blood flows back to the heart from the body's peripheral veins. It's an integral part of the circulatory system...
What is Venous Return?
Venous return refers to the rate at which blood flows back to the heart from the body's peripheral veins. It's an integral part of the circulatory system...
12.2K
01:26Muscles of the Pelvic Floor and Perineum
4.6K
The muscles of the pelvic floor and perineum are crucial for supporting the pelvic organs, controlling continence, and aiding in sexual function, childbirth, and core stability. They are typically divided into the superficial perineal layer and the deep pelvic floor layer.
Perineal Layer
The perineum is a diamond-shaped area below the pelvic diaphragm, divided into an anterior urogenital triangle that contains the external genitals and a posterior anal triangle housing the anus. The urogenital...
Perineal Layer
The perineum is a diamond-shaped area below the pelvic diaphragm, divided into an anterior urogenital triangle that contains the external genitals and a posterior anal triangle housing the anus. The urogenital...
4.6K
01:23Urinary Bladder
3.4K
The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
3.4K
01:18Velocity of an Object
199
Understanding how an object moves along a path requires distinguishing between motion over a time span and motion at a precise moment. A useful example is a vehicle traveling along a straight and level path, where its position at any given time is known. The initial step in analyzing this motion is to measure how far the vehicle travels over a fixed time period. This measurement, called average velocity, is computed by dividing the total change in position by the duration over which the change...
199
01:30Venous Thrombosis I: Introduction
433
Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
433
01:29Potential Due to a Polarized Object
770
A neutral atom consists of a positively charged nucleus surrounded by a negatively charged electron cloud. When placed in an external electric field, the external electric force pulls the electrons and nucleus apart, opposite to the intrinsic attraction between the nucleus and the electrons. The opposing forces balance each other with a slight shift between the center of masses of the nucleus and the electron cloud, resulting in a polarized atom. On the other hand, a few molecules, like water,...
770