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Transgenerational effects of obesogens.

Michelle Kira Lee1, Bruce Blumberg1,2,3

  • 1Department of Developmental and Cell Biology, University of California, Irvine, California.

Basic & Clinical Pharmacology & Toxicology
|February 26, 2019
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Summary
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Environmental obesogens, chemicals impacting fat storage, can cause obesity across generations. Prenatal exposure leads to lasting effects, even through chromatin alterations, highlighting the need for caution in chemical regulation.

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Area of Science:

  • Environmental Health
  • Endocrinology
  • Developmental Biology

Background:

  • Obesity is a global pandemic, with the traditional 'calories in-calories out' model insufficient to explain its complexity.
  • Environmental factors significantly influence obesity development, challenging conventional dietary and exercise explanations.

Purpose of the Study:

  • To explore the environmental obesogen model, which posits that early-life exposure to specific chemicals can predispose individuals to obesity.
  • To investigate the transgenerational effects of obesogen exposure and the underlying epigenetic mechanisms.

Main Methods:

  • Identification of various chemical obesogens.
  • Studies involving prenatal exposure of pregnant animals (F0 generation) to obesogens.
  • Analysis of effects on offspring up to the F4 generation.
  • Investigation of chromatin structure and accessibility alterations.

Main Results:

  • Chemical obesogens stimulate adipogenesis and fat storage.
  • Prenatal obesogen exposure causes lasting obesity predisposition in offspring for at least four generations.
  • Transgenerational effects are mediated by changes in chromatin structure and accessibility.

Conclusions:

  • Environmental obesogens pose a significant risk for obesity development and transmission across generations.
  • Epigenetic modifications, particularly in chromatin, play a crucial role in mediating these long-term effects.
  • The findings necessitate increased caution regarding the regulation of endocrine-disrupting chemicals and obesogens.