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Total Synthesis of Carthamin, a Traditional Natural Red Pigment
Kohei Azami1, Taiki Hayashi1, Takenori Kusumi1
1Department of Chemistry, Tokyo Institute of Technology, 2-12-1 O-okayama, Meguro-ku, Tokyo, 152-8551, Japan.
Abstract:
The first total synthesis of carthamin (3), a historic natural red pigment, has been achieved. The molecular structure was efficiently constructed by assembling two equivalents of the in situ generated lithiated monomers and triisopropyl orthoformate. This synthesis confirms the structure proposed in 1996.
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