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Fluorinated Para-Quinone Monoacetal: Versatile Reactivity for Constructing Functionalized Scaffolds
Kohei Azami1, Masao Morita2, Keisuke Suzuki1
1Department of Chemistry, Institute of Science Tokyo, Tokyo, Japan.
Abstract:
A concise synthetic route to the difluorinated para-quinone monoacetals (p-QMAs) and their reactivity is described. Featuring a cross-conjugated dienone core and an acetal unit, these compounds undergo diverse nucleophilic additions at the enone moiety and cycloadditions at the C═C bond. Such distinctive reactivity renders the β,β'-difluoro p-QMA a versatile building block for the rapid assembly of complex molecular architectures, highlighting its promise in natural product synthesis and material sciences.
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