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Detection of Ureaplasma spp. serovars in genital tract of infertile males

Tiejun Song1, Zhiwei Liu1, Ying Zhang1

  • 1Department of Clinical Laboratory, Sir Run Run Shaw hospital, School of medicine, Zhejiang University, Hangzhou, China.

Journal of Clinical Laboratory Analysis
|February 26, 2019
PubMed
Abstract

Insights

Ureaplasma species colonization is linked to male infertility. Ureaplasma parvum serovars 1 and 6, and Ureaplasma urealyticum serovar 9 are most common in infertile males.

Area of Science:

  • Microbiology
  • Reproductive Medicine
  • Genitourinary Health

Background:

  • Ureaplasma species colonization in the genital tract is associated with male infertility.
  • Limited studies suggest a link between Ureaplasma virulence and specific serotypes.
  • Understanding serovar distribution is crucial for diagnosing and managing male infertility.

Purpose of the Study:

  • To determine the prevalence of Ureaplasma serovars in infertile males.
  • To analyze the association between specific Ureaplasma serovars and male infertility.
  • To identify common Ureaplasma serovars in the male genital tract.

Main Methods:

  • Analysis of 358 urethral swab samples from infertile males.
  • Ureaplasma species identification using the Mycoplasma IST 2 kit.
  • Serovar determination via real-time polymerase chain reaction (real-time PCR).

Main Results:

  • Ureaplasma spp. detected in 25.7% (92/358) of infertile males.
  • Ureaplasma parvum (UPA) found in 79.3% (73/92) and Ureaplasma urealyticum (UUR) in 20.7% (19/92) of positive cases.
  • Common UPA serovars were 1 and 6 (63.0%); common UUR serovar was 9 (47.4%).

Conclusions:

  • This study first identified the distribution of 14 Ureaplasma serovars in infertile males using real-time PCR.
  • UPA serovars 1 and 6, and UUR serovar 9 are the most prevalent in the urogenital tracts of infertile males.
  • Findings contribute to understanding the role of Ureaplasma serovars in male infertility.
Keywords:
Ureaplasma parvumUreaplasma urealyticuminfertile malesreal-time PCRserovars

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