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Associations Between ABO Blood Groups and Diseases in the Digestive System and Vein
Feiyu Jiang1, Zhiwei Liu1, Ying Zhang1
1Department of Blood Transfusion, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People's Republic of China.
Insights
Individuals with non-O blood types have a higher risk of developing Crohn's disease (CD) and venous thrombosis (VT). This finding suggests non-O blood groups may serve as a new predictor for these conditions.
Area of Science:
- Medical Science
- Genetics
- Epidemiology
Background:
- The ABO blood group system is vital for transfusions but its association with digestive and venous diseases remains unclear.
- Understanding these links can improve disease prediction and management.
Purpose of the Study:
- To investigate the relationship between ABO blood groups and specific digestive system diseases and venous thrombosis.
- To determine if ABO blood type influences the risk of Crohn's disease (CD), ulcerative colitis (UC), stomach cancer (SC), colorectal cancer (CRC), pancreatic cancer (PC), liver cancer (LC), and venous thrombosis (VT).
Main Methods:
- A retrospective study analyzed ABO blood group distributions in 1432 CD, 416 UC, 1140 SC, 841 CRC, 384 PC, 520 LC, and 563 VT patients against 896 healthy controls (NC).
- Statistical analyses included unpaired t-tests, chi-squared tests, and multivariate logistic regression to assess associations between ABO blood groups and CD/VT.
Main Results:
- ABO blood group distributions did not significantly differ for UC, SC, CRC, PC, and LC patients compared to NC.
- However, CD and VT patients showed significant differences, with lower rates of type O and higher rates of type AB blood.
- Multivariate analysis confirmed that non-O blood types were associated with a higher risk of CD (OR=1.355) and VT (OR=1.465) compared to blood group O.
Conclusions:
- ABO blood group distributions in Crohn's disease and venous thrombosis patients significantly differ from healthy controls.
- Non-O blood groups may represent a novel predictive factor for the development of CD and VT.
Purpose:
The ABO blood type system is crucial for human blood transfusions. However, the relationships between ABO blood groups and diseases in the digestive system and vein have not been elucidated. We investigated the relationships between ABO blood groups and diseases in the digestive system and vein in this study.
Patients And Methods:
A retrospective study on a Chinese population, including 1432 Crohn's disease (CD), 416 ulcerative colitis (UC), 1140 stomach cancer (SC), 841 colorectal cancer (CRC), 384 pancreatic cancer (PC), 520 liver cancer (LC), and 563 venous thrombosis (VT) patients, was performed. Furthermore, 896 healthy subjects were enrolled as normal controls (NC) in this study. The demographic characteristics of patients and NC were compared using the unpaired t-test and χ2 test. Multivariate logistic regression model was used to evaluate the association between ABO blood groups and CD and VT.
Results:
ABO blood groups distributions in UC, SC, CRC, PC, and LC patients did not differ from that of NC, but CD and VT patients had significant difference of ABO blood group distribution from that of NC (p = 0.015 and p = 0.002, respectively). Patients with CD and VT had considerably lower rates of type O blood (p = 0.011 and p = 0.001, respectively) and significantly higher rates of type AB blood (p = 0.013 and p = 0.022, respectively) than those with NC. Multivariate logistic regression analysis showed the association of CD and VT with non-O blood types was still significant with a higher risk than with blood group O after adjusting for age and gender (OR = 1.355, 95% CI = 1.100-1.670, p = 0.004 and OR = 1.465, 95% CI = 1.131-1.903, p = 0.004, respectively).
Conclusion:
ABO blood groups distributions in CD and VT patients significantly differed from that of NC. Non-O blood group could be a new predictor for CD and VT.
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