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Fibroblast Growth Factors in Depression
Zheng Deng1, Sheng Deng2,3, Mu-Rong Zhang2,3,4
1Hospital Evaluation Office, Xiangya Hospital, Central South University, Changsha, China.
Frontiers in Pharmacology
|February 27, 2019
Summary
Major depressive disorder (MDD) is a serious public health issue with unclear causes. Fibroblast growth factors (FGFs) show a link to depression, suggesting potential biomarkers and new treatment targets.
Area of Science:
- Neuroscience
- Molecular Biology
- Psychiatry
Background:
- Major depressive disorder (MDD) is a significant global health concern.
- The underlying mechanisms of depression are not fully understood.
- Fibroblast growth factors (FGFs) play roles in brain development and maintenance.
Purpose of the Study:
- To review the association between the FGF system and depression.
- To explore FGFs as potential biomarkers for MDD diagnosis and prognosis.
- To investigate FGFs as novel therapeutic targets for depression.
Main Methods:
- Literature review of studies investigating FGFs and depression.
- Analysis of correlations between FGF system members and depressive states.
- Synthesis of current research on FGF signaling in the context of MDD.
Main Results:
- Evidence suggests a correlation between specific FGF members and depression.
- FGF signaling pathways are implicated in the pathophysiology of MDD.
- The FGF system represents a promising area for further research in depression.
Conclusions:
- The FGF system is potentially linked to the pathogenesis of depression.
- FGFs may serve as valuable biomarkers for MDD.
- Targeting the FGF system could offer new avenues for depression treatment.
Keywords:
depressionfibroblast growth factorfibroblast growth factor receptorhippocampusmajor depressive disorderMore Related Videos
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