Acute Renal Failure Secondary to Inadvertent Propylene Glycol Overdose with Single-Day High-Dose Vitamin D (Stosstherapy)
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Published on: December 27, 2013
David H Jelley1, Deborah Zayneb Mohamad Ali2, Michelle Condren3
1Pediatric Department, University of Oklahoma School of Community Medicine, Tulsa, 4444 E 41 St., Tulsa, OK 74135, 918-619-4803, USA.
Abstract:
Globally, there has been increasing attention paid to vitamin D deficiency and its treatment. Vitamin D stosstherapy with high-dose ergocalciferol in a single day is reemerging as a potential treatment option. We present an as yet unreported complication of acute renal injury due to propylene glycol toxicity in a 7-month infant treated with vitamin D stosstherapy. The product label for the vitamin D used for this patient states it is dissolved in propylene glycol (PG), but the amount is not listed on this or other US ergocalciferol liquid products that contain PG. Caution should be used when considering vitamin D stosstherapy with liquid ergocalciferol products available in the United States.
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