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Creating Dynamic Images of Short-lived Dopamine Fluctuations with lp-ntPET: Dopamine Movies of Cigarette Smoking
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Classical dopamine agonists

R Horowski1, P-A Löschmann2

  • 1Antaxios GmbH, Zum Weiher 44, 14552, Wildenbruch, Germany. r.horowski@aramon.de.

Journal of Neural Transmission (Vienna, Austria : 1996)
|February 27, 2019
PubMed

Insights

Arvid Carlsson

Area of Science:

  • Neuroscience
  • Pharmacology
  • Neurology

Background:

  • Pioneering research by Arvid Carlsson established dopamine (DA) as a key neurotransmitter.
  • This discovery revolutionized the treatment of central nervous system (CNS) diseases.

Observation:

  • Carlsson's work led to therapies for Parkinson's disease (PD) using L-DOPA and other dopaminergic drugs.
  • Different DA agonists like apomorphine, bromocriptine, and lisuride exhibit varied administration routes and efficacy.

Findings:

  • Lisuride demonstrates high dopamine receptor affinity and versatile administration (oral, parenteral, transdermal).
  • Carlsson explored presynaptic DA agonist effects and partial agonism as novel therapeutic strategies.

Implications:

  • These findings form the basis for current symptomatic treatments of Parkinson's disease.
  • Innovative mechanisms for treating PD and schizophrenia, including presynaptic effects and partial agonism, were conceptualized.
Keywords:
ApomorphineBromocriptineLisuride

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