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Directed C3-Alkoxymethylation of Indole via Three-Component Cascade Reaction
Chao Pi1, Xiaohang Yin1, Xiuling Cui1
1College of Chemistry and Molecular Engineering, Henan Key Laboratory of Chemical Biology and Organic Chemistry, Key Laboratory of Applied Chemistry of Henan Universities , Zhengzhou University , Zhengzhou 450052 , P. R. China.
Abstract:
An efficient and regioselective C3-alkoxymethylation of indoles has been developed with aldehydes and alcohols via three-component cascade reaction under transition-metal free conditions. This method allows for rapid access to a variety of C3-alkoxymethylaed free (N-H) indole in up to 98% yield with excellent regioselectivity. The titled products are useful building blocks in organic synthesis.
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