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Multifactor Analysis of Thyroid Stiffness in Graves Disease: A Preliminary Study
Shimei Li1, Jiyi Yao1, Shaoyun Hao1
1Department of Ultrasound, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 107 Yanjiangxi Rd, Guangzhou 510120, China.
AJR. American Journal of Roentgenology
|February 27, 2019
Summary
Shear wave elastography (SWE) can help diagnose Graves disease (GD). Factors like disease duration, thyroid size, and autoantibody levels influence thyroid stiffness in GD patients.
Area of Science:
- Endocrinology
- Medical Imaging
- Rheumatology
Background:
- Graves disease (GD) is an autoimmune disorder causing hyperthyroidism.
- Thyroid stiffness is a potential diagnostic indicator in GD.
- Shear wave elastography (SWE) measures tissue stiffness quantitatively.
Purpose of the Study:
- To evaluate the diagnostic value of SWE in Graves disease.
- To identify factors influencing thyroid stiffness in GD patients.
Main Methods:
- 207 subjects (162 GD patients, 45 controls) underwent SWE.
- Thyroid elastic modulus values (SWE mean) were measured.
- Hormone levels (FT3, FT4, TSH) and autoantibodies (TPO Ab, TG Ab, TR Ab) were assessed.
Main Results:
- GD patients exhibited significantly higher SWE values than controls.
- SWE mean showed an AUC of 0.656 for GD diagnosis.
- Disease duration, thyroid size, isthmus thickness, and autoantibody levels correlated positively with SWE mean.
Conclusions:
- Quantitative SWE is a valuable tool for diagnosing Graves disease.
- Thyroid stiffness in GD is influenced by disease duration, thyroid size, and autoantibody levels.
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