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Related Experiment Video

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Recurrent corneal erosion: a comprehensive review.

Darby D Miller1, Syed A Hasan1, Nathaniel L Simmons2

  • 1Department of Ophthalmology, Mayo Clinic, Jacksonville, FL 32224, USA, miller.darby@mayo.edu.

Clinical Ophthalmology (Auckland, N.Z.)
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Summary

Recurrent corneal erosion (RCE) management involves various treatments, from conservative drops to advanced surgical options. New therapies individualize care and reduce RCE recurrence rates.

Keywords:
anterior basement membrane dystrophycorneal abrasionepithelial basement membrane dystrophymap-dot-fingerprint dystrophyrecurrent corneal erosion

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Area of Science:

  • Ophthalmology
  • Corneal Diseases
  • Ocular Surface Disease

Background:

  • Recurrent corneal erosion (RCE) is often linked to basement membrane dystrophies, trauma, or prior eye surgery.
  • Diagnosis requires slit-lamp examination and suspicion, as symptoms include sharp pain upon waking.
  • Traditional treatments include lubricating drops, cycloplegics, and analgesics, with bandage contact lenses for persistent cases.

Purpose of the Study:

  • To provide a comprehensive literature review of recurrent corneal erosion (RCE).
  • To outline current and novel treatment options for RCE management.
  • To offer recommendations for the clinical approach to RCE.

Main Methods:

  • Literature review of RCE treatments.
  • Analysis of conservative and surgical management strategies.
  • Evaluation of newly introduced therapies.

Main Results:

  • Conservative treatments include lubricants, pain control, and bandage contact lenses.
  • Newer therapies include MMP inhibitors, blood-derived drops, amniotic grafts, and corticosteroids.
  • Surgical options like debridement, stromal puncture, and laser therapies are effective for refractory cases.

Conclusions:

  • Individualized therapy based on new treatments can lower RCE recurrence.
  • A range of options exists, from conservative to surgical, for managing RCE.
  • Effective management strategies aim to heal the epithelium and prevent future erosions.