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New oral and topical approaches for the treatment of melasma

P E Grimes1,2, S Ijaz1, R Nashawati1

  • 1Vitiligo & Pigmentation Institute of Southern California, Los Angeles, California.

International Journal of Women'S Dermatology
|February 28, 2019
PubMed

Insights

Melasma, a common hyperpigmentation disorder, presents complex causes and relapsing nature. New oral and topical treatments offer expanded therapeutic options for patients.

Area of Science:

  • Dermatology
  • Hyperpigmentation Disorders

Background:

  • Melasma is a frequent, challenging skin hyperpigmentation disorder, primarily affecting women with Fitzpatrick Skin Types III-VI.
  • Its pathogenesis is multifactorial, involving genetic predisposition, UV radiation, and hormonal factors.
  • Current treatments involve a combination of photoprotection, lightening agents, and procedures.

Purpose of the Study:

  • To review novel and emerging oral and topical treatments for melasma.
  • To update clinicians on the expanding therapeutic landscape for this condition.

Main Methods:

  • Literature review of recent studies on melasma treatments.
  • Synthesis of information on new oral and topical therapeutic agents.

Main Results:

  • Emerging treatments show promise in managing melasma.
  • New agents are expanding the options beyond traditional therapies.

Conclusions:

  • Advances in understanding melasma pathogenesis are driving the development of new treatments.
  • The therapeutic armamentarium for melasma is growing with new oral and topical options.
Keywords:
Melasmalightening agentsnew and emergingoral treatmentsphotoprotectiontopical treatments

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