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Early Lessons from the Implementation of Genomic Medicine Programs
1Genomic Medicine Institute, Geisinger, Danville, Pennsylvania 17822-2620, USA;
Annual Review of Genomics and Human Genetics
|February 28, 2019
Summary
Massively parallel sequencing is advancing precision medicine in clinical settings. Implementation science within learning health systems accelerates its adoption in pharmacogenomics, diagnostics, tumor characterization, and screening.
Area of Science:
- Genomic Medicine
- Implementation Science
- Health Services Research
Background:
- Massively parallel sequencing (MPS) is transitioning from research to clinical practice.
- Precision medicine relies on integrating advanced genomic technologies into healthcare.
- The learning health-care system framework supports evidence-based clinical practice improvements.
Purpose of the Study:
- To examine the application of MPS in four key clinical scenarios.
- To identify enablers and challenges in implementing MPS programs.
- To provide lessons for accelerating precision medicine adoption.
Main Methods:
- Review of MPS applications in pharmacogenomics, diagnostics, somatic tumor testing, and population screening.
- Analysis of exemplar programs showcasing implementation strategies.
- Inclusion of international case studies.
Main Results:
- Successful MPS implementation leverages implementation science within learning health systems.
- Pharmacogenomics, diagnostics, somatic testing, and population screening are key application areas.
- Exemplar programs highlight critical factors for successful integration.
Conclusions:
- Early lessons from MPS implementation can guide future precision medicine initiatives.
- Addressing enablers and challenges is crucial for widespread adoption.
- Accelerating the integration of MPS will enhance precision health outcomes.
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