Disruption of corticospinal plasticity by 6-hydroxydopamine as measured by intracortical microstimulation in rats

Intracortical microstimulation in normal, adult rats evoked low-threshold contralateral and high-threshold ipsilateral forelimb movements. In comparison, stimulation of the intact cortex in adult rats that sustained unilateral cortical lesions at birth evoked ipsilateral movements at abnormally low-threshold levels in addition to normal contralateral movements. Depletion of cortical and spinal cord noradrenaline levels by treatment with 6-hydroxydopamine prior to the placement of neonatal cortical lesions eliminated the low-threshold ipsilateral movements when tested at maturity. These findings suggest that the noradrenergic system may influence corticospinal plasticity.