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Updated: Jan 28, 2026
06:14
Expansion of Two-dimension Electrospun Nanofiber Mats into Three-dimension Scaffolds
Published on: January 7, 2019
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Stabilization of chitosan based electrospun nanofibers through a simple and safe method
Milad Fadaie1, Esmaeil Mirzaei2, Zahra Asvar2
1Department of Medical Nanotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran; Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Summary
This study presents a simple water vapor treatment to stabilize chitosan nanofibrous mats, preserving structure and enhancing mechanical properties and cell compatibility for biomedical applications.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Nanotechnology
Background:
- Chitosan (CS) nanofibrous mats are promising biomaterials but require stabilization for use in aqueous environments.
- Conventional crosslinking methods can introduce toxicity and alter material properties unfavorably.
Purpose of the Study:
- To develop a simple, safe, and effective method for stabilizing electrospun chitosan/polyethylene oxide nanofibrous mats.
- To evaluate the impact of water vapor treatment on the structural integrity, chemical properties, mechanical performance, and biological compatibility of chitosan mats.
Main Methods:
- Electrospinning of chitosan/polyethylene oxide in acetic acid solution to form nanofibrous mats.
- Stabilization of mats via exposure to water vapor at controlled temperature (40-70°C) and time (30-120 min).
- Characterization using Scanning Electron Microscopy (SEM), Infrared (IR) spectroscopy, Thermogravimetric Analysis (TGA), and tensile testing.
Main Results:
- Water vapor treatment successfully preserved the nanofibrous structure of chitosan mats after immersion in phosphate-buffered saline (pH 7.4).
- Treatment removed acetic acid residues, neutralized the mats, and increased tensile strength and elastic moduli.
- Compared to glutaraldehyde cross-linked mats, water vapor treated mats exhibited higher swelling ratios and enhanced cell compatibility.
Conclusions:
- Water vapor treatment is a safe and effective method for stabilizing chitosan nanofibrous mats.
- This stabilization method improves mechanical properties and cell compatibility without compromising structural integrity.
- The developed technique offers a promising alternative to conventional crosslinking for chitosan-based biomaterials.
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