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Updated: Jan 28, 2026

Design and Development of Aptamer&#8211;Gold Nanoparticle Based Colorimetric Assays for In-the-field Applications
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Resorcinol Functionalized Gold Nanoparticles for Formaldehyde Colorimetric Detection.

Carlos Martínez-Aquino1, Ana M Costero2,3,4, Salvador Gil5,6,7

  • 1Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat Politécnica de València, Universitat de València, Doctor Moliner 50, Burjassot, 46100 Valencia, Spain. carlos.martinez-aquino@uv.es.

Nanomaterials (Basel, Switzerland)
|March 1, 2019
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Summary

Researchers developed gold nanoparticles to detect formaldehyde gas and in solutions. This color-changing probe offers a sensitive method for monitoring formaldehyde, even from composite wood boards.

Keywords:
colorimetric detectionformaldehydegold nanoparticlesresorcinol

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Area of Science:

  • Nanotechnology
  • Chemical Sensing
  • Environmental Monitoring

Background:

  • Formaldehyde is a common indoor air pollutant with health risks.
  • Accurate detection of formaldehyde is crucial for environmental and health safety.
  • Existing detection methods can be complex or lack sensitivity.

Purpose of the Study:

  • To develop a novel sensor for formaldehyde detection.
  • To utilize gold nanoparticles for sensitive and visual formaldehyde sensing.
  • To assess the probe's applicability in detecting formaldehyde emissions from materials.

Main Methods:

  • Synthesis of gold nanoparticles functionalized with resorcinol moieties.
  • Utilizing nanoparticle aggregation and color change for formaldehyde detection.
  • Determining the limit of detection in solution and evaluating gas-phase detection.

Main Results:

  • Successfully prepared gold nanoparticles functionalized with resorcinol.
  • Demonstrated a colorimetric detection mechanism for formaldehyde based on nanoparticle aggregation.
  • Achieved a limit of detection of 0.5 ppm for formaldehyde in solution.
  • Showcased potential for detecting formaldehyde emissions from composite wood boards.

Conclusions:

  • The developed gold nanoparticle probe is effective for detecting formaldehyde in both solution and gas phases.
  • The colorimetric response provides a simple and visual method for formaldehyde sensing.
  • The probe shows promise for real-world applications, such as monitoring formaldehyde from building materials.